MA Huiqin,ZHAN Leyun,XU Qingwen.Advances in research on factors influencing the analgesic effect of opioids[J].Perioperative Safety and Quality Assuance,2019,3(03):172-176.[doi:10.3969/j.issn.2096-2681.2019.03.012]


《麻醉安全与质控》[ISSN:2096-1245/CN:CN 61-1505/R]



Advances in research on factors influencing the analgesic effect of opioids
马会芹 占乐云 许晴雯
三峡大学人民医院麻醉科, 湖北 宜昌 443000
MA Huiqin ZHAN Leyun XU Qingwen
Department of Anesthesiology, The People’s Hospital of China Three Gorges University, Yichang 443000, China
阿片类药物 镇痛 基因多态性 年龄 性别 肥胖
opioids analgesia genetic polymorphism age gender obesity
阿片类药物是目前应用最广泛的镇痛药, 其镇痛效果在个体之间存在广泛差异, 造成这些差异的因素有很多, 其中遗传因素占有重要的地位, 药物代谢酶、 转运蛋白、 受体和药物作用靶点的基因多态性特别是基因的单核苷酸多态性(SNP)是引起阿片类药物效应和副作用个体差异的重要原因。 此外, 还包括年龄、 性别、 肝病肾病、 肥胖等因素对其镇痛效果也会产生一定的影响, 本文对关于这些影响因素的研究进行综述, 从而指导临床阿片类药物的用药。
Opioids are the most widely used analgesic drugs at present, and their analgesic effects wary widely among individuals. There are many factors that can cause these differences, among which genetic factors play an important role. Drug metabolism enzymes, transporters, receptors, and genetic polymorphisms of drug targets in particular gene single nucleotide polymorphisms (SNPs) are also important causes of individual differences in opioid drug effects and side effects. In addition, age, gender, liver disease, kidney disease, obesity and other factors may also have a certain impact on the analgesic effects. This article reviews the research on these influencing factors to guide the clinical use of opioiods.


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收稿日期: 2018-10-27; 接受日期: 2018-12-03
基金项目: 宜昌市医学拔尖人才培养工程(2017年)
作者简介: 马会芹, 硕士研究生, E-mail: 297186050@qq.com
通信作者: 占乐云, E-mail: Leyunzhan@163.com
更新日期/Last Update: 2019-06-15